Article: A COMPREHENSIVE REVIEW ON PISHTI KALPANA

Article Category: Review articles

DOI: 10.7897/2277-4343.165183

Pages: 128-133

Author: Gunjan Thapliyal *, Khem Chand Sharma

Abstract: Pishti Kalpana, a classical Ayurvedic dosage form, refers to a finely ground preparation obtained through trituration (Bhavana) of minerals, gemstones, or calcium-rich substances with specific liquid media. This unique pharmaceutical process not only detoxifies the raw material by eliminating impurities but also enhances its bioavailability, rendering the final product therapeutically potent and comparable in efficacy to Bhasma formulations. Though traditionally aligned with Ayurvedic practice, Pishti Kalpana is also prominently utilized in Unani medicine systems. Commonly used substances in Pishti preparations include calcium-based compounds such as Mukta (pearl) and Pravala (coral), as well as various gemstones and semi-precious stones (Ratna and Upratna) like Manikya (ruby), Gomed (Zircon), Panna (emerald), and Neelam (sapphire). The choice of Bhavana media such as Gulab Arka (rose water), Kewda Arka, and Ghritkumari (Aloe vera juice) is therapeutically tailored according to the targeted pathology. Recent scientific interest in Pishti has surged due to its microfine particle size and rapid absorption potential, positioning it within the emerging domain of traditional nanomedicine. This review aims to provide a comprehensive overview of Pishti Kalpana, including its traditional manufacturing techniques, therapeutic indications, recent analytical studies, safety evaluations, and its relevance in modern pharmaceutics as a potential form of nano-delivery system.

Keyword: Pishti, Nanomedicine, Gems