Article: THERAPEUTIC EFFICACY OF CHUKKUCHUNDADI KASHAYA IN SHOPHA: AN EXPERIMENTAL EVALUATION

Article Category: Original Research articles

DOI: 10.7897/2277-4343.17115

Pages: 85-91

Author: Krathi *, Rachana C, Parikshita Navada, Savitha

Abstract: Aim: To evaluate the Shophahara (anti-inflammatory) efficacy of Chukkuchundadi Kashaya through an experimental study. Method: A pharmaceutical study was conducted to prepare Chukkuchundadi Kashaya in college pharmacy following standard operating procedure. The experimental evaluation was carried out using the carrageenan-induced paw oedema model to assess the anti-inflammatory activity of the formulation. The reduction in paw oedema was measured and statistically analyzed. Results: The experimental study showed reduction in paw oedema with increase in Jarana shakti (time taken for ahara pachana) and Abhyavarana shakti (matra and frequency of ahara in relation to appetite) in the group treated with Chukkuchundadi Kashaya without any side effects when compared to standard and control group. The findings indicate that the formulation possesses appreciable anti-inflammatory activity. Discussion: Chukkuchundadi Kashaya is formulated based on classical Ayurvedic principles and contains drugs with Kaphavatahara, Amapachana, and Shothaghna properties. The observed anti-inflammatory effect may be attributed to the combined and synergistic action of its ingredients, which helps in improving Agnidipana, facilitating Vatanulomana and promoting Strotoshodhana. These actions collectively help in breaking the Samprapti of Shopha. Conclusion: The study concludes that the Chukkuchundadi Kashaya exhibits significant anti-inflammatory activity in an experimental model. The results support its potential utility as an effective Ayurvedic formulation for the management of inflammatory conditions associated with Shopha.

Keyword: Chukkuchundadi Kashaya, Anti-inflammatory, Shopha, Carrageenan- induced paw oedema.