Article: SYNERGISTIC EFFECT OF ZINGIBER OFFICINALE AND ALLIUM SATIVUM AGAINST PLATELET AGGREGATION

Article Category: Original Research articles

DOI: 10.7897/2277-4343.17116

Pages: 92-96

Author: Mohamed Fiaz A *, Anand Babu K

Abstract: Platelet aggregation, a pathological process in which platelets adhere to blood vessels and release inflammatory mediators, contributes to vascular and cardiac complications. This study evaluated the in-vitro synergistic anti-platelet activity of Zingiber officinale (ginger) and Allium sativum (garlic). Fresh and dried extracts were prepared using the maceration technique, and phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, and glycosides. The anti-platelet effect was assessed using platelet-rich plasma and platelet-poor plasma obtained from a healthy poultry bird. A mixture of garlic and ginger extracts in a 5:1 ratio demonstrated significant inhibition of platelet aggregation in both fresh (p < 0.01) and dried (p < 0.01) extracts, with dried extracts exhibiting the highest percentage of platelet inhibition. These findings suggest that the combination of Zingiber officinale and Allium sativum has potent synergistic anti-platelet activity, supporting its potential role as a natural therapeutic agent against platelet-mediated vascular disorders.

Keyword: Zingiber officinale, Allium sativum, platelet aggregation, anti-platelet activity, phytochemicals