Article: A RANDOMISED COMPARATIVE CLINICAL STUDY TO EVALUATE THE RELATIVE EFFECT OF PRAGBHAKTA AND ADHOBHAKTA AUSHADHA SEVANA KALA IN GRIDHRASI

Article Category: Original Research articles

DOI: 10.7897/2277-4343.17255

Pages: 78-80

Author: Parikshith K *, Satyanarayana B, J Dinesh Nayak

Abstract: Background: Aushadha Sevana Kala (time of drug administration) is an important Ayurvedic principle that optimizes drug efficacy by aligning treatment with physiological rhythms. Chronopharmacology supports time-dependent variations in disease activity and drug response. Despite detailed classical descriptions, clinical validation of this concept remains limited. Aim: To evaluate the clinical impact of Aushadha Sevana Kala on therapeutic outcomes using Vatagajankusha Rasa in Gridhrasi (Sciatica). Materials and Methods: A randomized comparative clinical study was conducted on 30 Gridhrasi patients, divided into two groups (n=15 each). Group A received Vatagajankusha Rasa in Pragbhakta Kala (before food), while Group B received it in Adhobhakta Kala (after food) for 15 days. Assessments were done at baseline, post-treatment, and one-week follow-up, with intra- and inter-group statistical analysis. Results: Both groups showed statistically significant improvement in all clinical parameters. Group A (Pragbhakta Kala) demonstrated comparatively better clinical improvement. Inter-group comparison revealed a statistically significant difference only in stiffness (P < 0.05), while other parameters did not show statistically significant differences. Conclusion: The study supports the classical concept of Aushadha Sevana Kala, emphasizing the role of proper drug timing in improving therapeutic outcomes in Gridhrasi. Further large-scale studies are needed to validate these findings across different conditions.

Keyword: Aushadha Sevana Kala, Chronotherapeutics, Circadian rhythm, Gridhrasi, Vatagajankusha Rasa, Drug Administration Timing.