Article: AN OPEN-LABEL, SINGLE-ARM, SINGLE-CENTERED CLINICAL STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND EFFICACY OF MINTDROPS TOOTH TABS IN IMPROVEMENT OF ORAL HYGIENE

Article Category: Original Research articles

DOI: 10.7897/2277-4343.17263

Pages: 131-136

Author: Pillalamarri VSSR Anjaneyulu, Erepalli Sreekanth *

Abstract: Oral health hygiene is essential for maintaining gingival health and preventing plaque accumulation, halitosis, and inflammatory oral conditions. Limitations of conventional toothpaste formulations, including compliance challenges and environmental concerns, have encouraged the development of alternative oral care formats. Mintdrops Tooth Tabs are a tablet-based toothpaste designed to offer a sustainable and convenient alternative. Objective: To evaluate the safety, tolerability, and efficacy of Mintdrops Tooth Tabs in improving oral hygiene over a 30-day period. Methods: This open-label, single-arm, single-center Phase 3 clinical study enrolled 130 healthy adults aged 18–65 years with a tendency for plaque formation. Participants replaced their regular toothpaste with Mintdrops Tooth Tabs, used twice daily for 30 days. Efficacy was assessed using the Modified Quigley–Hein Plaque Index (MQHPI) and Gingival Index (GI). Secondary outcomes included self-reported measures of oral health perception, gum comfort, and breath freshness. Statistical analysis was performed using paired t-tests with significance set at p < 0.05. Results: Significant improvements (p < 0.001) were observed in plaque scores and gingival health parameters. Mean plaque index scores improved from 1.45 to 2.00, and gingival inflammation showed marked resolution by Day 30. Participant-reported outcomes, including breath freshness and perceived gum health, also improved. All participants completed the study, and no adverse events were reported. Conclusion: Mintdrops Tooth Tabs were safe, well tolerated, and effective in improving oral hygiene, supporting their use as an alternative to conventional toothpaste.

Keyword: Oral hygiene, toothpaste tablets, plaque index, gingival index, clinical trial