Article: PATHOPHYSIOLOGICAL ROLE OF DHATWAGNI DUSHTI IN CHRONIC METABOLIC DISORDERS: AN INTEGRATIVE REVIEW

Article Category: Review articles

DOI: 10.7897/2277-4343.17268

Pages: 154-157

Author: Akanksha Chauhan *

Abstract: Ayurveda emphasizes Agni (digestive and metabolic fire) as the fundamental determinant of health and disease. Among its various forms, Dhatwagni governs metabolism at the level of individual Dhatus (body tissues) and is responsible for their proper transformation and nourishment. Impairment of Dhatwagni, known as Dhatwagni Dushti, results in defective tissue metabolism, accumulation of metabolic by-products, and progressive Dhatu dysfunction. Chronic metabolic disorders such as obesity, type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease, and metabolic syndrome are characterized by deranged glucose and lipid metabolism, insulin resistance, mitochondrial dysfunction, and chronic low-grade inflammation. These pathological features show close conceptual parallels with Dhatwagni Dushti described in classical Ayurvedic literature. This review explores the concept of Dhatwagni and its pathological states as explained in Ayurvedic texts and correlates them with contemporary biomedical mechanisms involved in chronic metabolic disorders. Understanding this interface may provide a holistic and integrative framework for diagnosis, prevention, and management of metabolic diseases through Agni-centric Ayurvedic principles.

Keyword: Dhatwagni, Dhatwagni Dushti, metabolic disorders, Ayurveda, tissue metabolism